The Approach
We believe our approach of combining the mechanistic certainty of target-based discovery with the richness and power of disease-relevant phenotypic assays represents a novel and direct approach to addressing challenging drug targets. This approach should have the potential for decreased off-target toxicities and the possibility of leveraging a wide array of cellular mechanisms responsible for modulating protein stability.
Discovery Process
By screening in an intact and natural cellular environment, we can rapidly identify small molecule binders to targets of interest with a high degree of specificity. When combined with high content phenotypic secondary assays, we can pursue targets that are either too challenging to drug with conventional discovery methods or have not been amenable to drugging with a small molecule.
